HyaGlo®
Learn about the power of hyaluronic acid The science behind the formulation of our natural wellness and skincare products.
Hyaluronan is the accepted scientific nomenclature for hyaluronic acid (HA) and physiological salts of hyaluronate, the conjugate base of hyaluronic acid.
The bottom line is that hyaluronan is necessary for your body to function, and as we get older, we need to consider a natural way to replenish it, not only in our skin and joints, but throughout the entire body.
Our Patented Hyaluronic Acid
- Active ingredient in all Baxyl® products
- Fully-hydrated hyaluronan supplement
- Proven results through clinical research
- Liquid supplementation with MHB3 is proven to be 3.8x more effective than dry forms of hyaluronic acid
- 8 U.S. Patents for prevention & maintenance of osteoarthritis, osteopenia (precursor to osteoporosis), osteophytes (bone spurs), and joint support
Bone and Joint Health
Hyaluronan is canonically recognized for its role in maintaining joint health. Hyaluronan is naturally synthesized locally by synoviocytes within the joint, and once produced, it binds to collagen and elastin to form articular cartilage. It is the presence of hyaluronan that makes cartilage strong enough to handle compressive forces within the joint (Seog, 2002).
Hyaluronan is also found in the synovial fluid, where it provides the major source of lubrication, allowing smooth fluid movement in joints (Sabaratnam, 2005).
Hyaluronan within the synovial capsule is critical for smooth joint movement: the articular cartilage encapsulates the ends of the bones, forming a smooth, low-friction surface, while synovial fluid forms a film of lubrication over the articular cartilage during movement. Combined, these structures protect the bones from frictional grinding (Walker, 1968).
Within the bone itself, hyaluronan primarily plays roles in bone modeling and remodeling. Hyaluronan has been shown to regulate bone remodeling by stimulating osteoblasts and osteocytes and inhibiting osteoclasts (Bastow, 2008; Prince, 2004). Intriguingly, hyaluronan taken orally has been shown to reduce urinary markers of bone resorption and ovariectomy-induced bone loss (Gerdin, 1997), indicating that hyaluronan may suppress bone resorption.
Scientific & Effective Ingredients
Astaxanthin
Found only in Baxyl® Sport, astaxanthin is a natural red algae that acts as an antioxidant and supports soft tissue health, muscular and exercise recovery. Because astaxanthin is an aquatic algae, it has a briny aftertaste. Athletes and those who regularly work on their feet and legs can benefit from daily astaxanthin use. Taken twice daily, users begin to notice results in a few short weeks.
Don’t let the fear of aching joints prevent you from enjoying running, walking or enjoying other sports and entertainment you enjoy or keep you from performing your job when on your feet and legs for hours at a time.
A.O. Prebiotic
Aspergillus oryzae (A.O. Prebiotic) was created by our parent company, BioZyme® Inc, using a proprietary, multi-step process that has been refined over the last 70 years. AO-Biotics® Amaferm®, found in Baxyl® GI, is a research-proven prebiotic that enhances digestibility while supporting a healthy gut microbiota. With 70% of the immune response found in the digestive tract, a prebiotic like AO-Biotic Amaferm helps improve your overall health. There are numerous varieties of AO found in food and health products; however, all mentions of AO in our products reference our proprietary strain.
Lion's Mane Extract
Lion’s mane extract is derived from lion’s mane mushrooms, which are found to be very nutrient-dense and filled with essential vitamins and minerals. The lion’s mane mushrooms are rich in thiamine, riboflavin, niacin, manganese, zinc and potassium.
Research shows that the lion’s mane extract is rich in beta-glucan content that supports enhanced gastroprotection and further encourages the growth of good gut bacteria with prebiotic fiber. Lion’s mane mushrooms are a great source of oligosaccharides, a specific type of carbohydrate that has many critical biological functions, including antioxidative and anti-tumor activities.
Skin
One of the primary functions of hyaluronan is maintaining tissue hydration. Interestingly, hyaluronan is so hydrophilic that it can absorb, retain, and deliver over one thousand times its weight in water (Wand, 2007). The molecule's ubiquitous nature ensures hydrophilic delivery throughout all tissues. Hyaluronan is most prevalent in the skin; approximately half of the total body hyaluronan is found in the dermal and epidermal layers. The primary functions of hyaluronan in the skin include moisturization and hydration (Meyer, 1941).
Skin turgor is the result of the ability of hyaluronan to absorb, retain, and deliver water (Wang, 2007). With age, there is a distinct decrease in the percent composition of hyaluronan in epidermal tissue, likely correlating with increased wrinkles and aged skin (Juhlin, 1997). Experiments have demonstrated that 77% of naturally occurring hyaluronan in the skin is lost by age 70 in humans (Weist, 2008).
HyaGlo®
For the skin to benefit from topical HA, the molecule must be readily available for absorption. High-molecular-weight hyaluronic acid is not small enough to be absorbed and so lies on the surface of the skin. On the other hand, low-molecular-weight hyaluronic acid is absorbed by the skin and penetrates more deeply. Specifically, Glysyn Hyaluronan is tailored at the molecular level for topical application and optimized for transdermal delivery and absorption.
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Baxyl®
Research indicates that little of the high-molecular-weight dry form is absorbed before excretion. While some low-molecular-weight dry forms may be hydrated and absorbed during ingestion and digestion, they are not effective and may even be detrimental to joint health. A study conducted with CSG’s patented liquid MHB3® Hyaluronan showed it significantly outperformed a dry, tableted HA dosage form (Hefner, 2012).
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Keep up to date with all the latest news and research, or spend some time learning about the science that backs your favorite Baxyl and HyaGlo products.
Frequently Asked Questions
What is hyaluronan?
Hyaluronan is a molecule naturally produced and found in all mammalian tissues. It initiates healing, retains moisture, lubricates, and absorbs shock in joints.
What is the molecular weight of a hyaluronan molecule?
Molecular weight refers to the size of the HA molecule. The molecular weight of hyaluronan is critical to its functionality and bioavailability. Low molecular weight HA (<500,000 Daltons) is considered pro-inflammatory and can have negative effects. HA with a high molecular weight (>3 million Daltons) is too large to be absorbed well. The MHB3 Hyaluronan used in Hyaluronex hits the sweet spot, with a range of 750,000-2.5 million Daltons.
Where does the MHB3® molecule come from?
MHB3® is made via a process called microbial fermentation. It is a very similar process to how penicillin or yogurt is made. This process gives us a molecule that has no animal or plant by-products. So, it is completely vegan, allergy-free, gluten-free, and soy-free.
Why is low molecular weight hyaluronic acid better for skincare?
For the skin to benefit from the topical use of HA, the molecule must be readily available for the skin to absorb. High molecular weight hyaluronic acid is not small enough for absorption and so, it lies on top of the skin. On the other hand, low molecular weight hyaluronic acid is absorbed by the skin and penetrates deeper. Specifically, Glysyn Hyaluronan is tailored at the molecular level for topical application and optimized for transdermal delivery and absorption.
Why are liquid formulations important?
The body cannot absorb hyaluronic acid molecules unless they are fully hydrated. Because HA molecules are extremely water-loving, they can hold up to 1000 times their weight in water. Dry forms of HA (pills, tablets, capsules & powders) do not have enough time to fully hydrate before being passed through the body’s digestive tract. Essentially, dry forms are not absorbed by the body and, therefore much less effective. The primary absorption points for HA throughout the body are in the mucosal tissue of the mouth and the upper parts of the throat. To take advantage of the absorption points, the supplement must be bioavailable for immediate absorption as soon as it hits your mouth. Therefore, we will continue to offer only fully hydrated, bioavailable HA supplements that are guaranteed to deliver results.