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Image: Beezie Madden & Cortes C

Now with a New Look and Formula!


“Two focuses of our Madden Method are longevity and preventing injuries before they happen, whenever possible. We aim to have horses with long, healthy and happy careers followed by long, happy and healthy retirements. We have fed Hyaluronex daily to our competition horses for over 10 years and trust their scientific research and high quality ingredients to protect and support our horse’s joint health.” – John and Beezie Madden, John Madden Sales, Inc.


Hyaluronex® is a premium equine joint supplement that relieves stiffness, enhances flexibility, and promotes healthy cartilage and joint function by delivering the most highly researched and proven hyaluronan (HA) available – MHB3® Hyaluronan (seven U.S. Patents). Hyaluronex now also contains Hydroxytyrosol and Astaxanthin to amplify the benefits of HA alone and help to more fully support joint soundness, soft tissue health, and promote exercise recovery.


Hyaluronex offers 240mgs of MHB3 Hyaluronan, 180mg Hydroxytyrosol, and 90mg Astaxanthin per ounce and is tailored for horses at all activity levels. Hyaluronex bolsters healthy articulation, maintains joint health, alleviates performance-related discomfort, and maximizes performance.


Hyaluronex provides daily support for joint health and complies with equine anti-doping regulations. Our patented formulation is researched and recommended by leading veterinarians. Hyaluronex is made in Lexington, Kentucky, and contains fully traceable, non-Chinese ingredients.



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Hyaluronan, also known as hyaluronic acid (HA) is a long, unbranched polysaccharide. The polymer chain of hyaluronan ranges in molecular weight from hundreds of units (or Daltons) up to several million.


Hyaluronan is found throughout the body in dense concentrations in cartilage, synovial fluid, skin, vertebral discs, bones, urinary tract, cardiac valves, eyes, and various other soft tissue.


Hyaluronan is most recognized for its role in the maintenance of joint health. It is synthesized within the joint and once produced, binds to collagen and elastin to form articular cartilage. It is the presence of hyaluronan that makes cartilage strong enough to handle compressive forces. Hyaluronan is also found in the synovial fluid, where it provides the major source of lubrication that allows for smooth fluid movement.


Thus, hyaluronan is critical for smooth joint movement: articular cartilage encapsulates the ends of the bones forming a smooth surface while synovial fluid lubricates the articular cartilage during movement. Within the bone itself, the presence of hyaluronan is primarily linked to its roles in the bone modeling and remodeling processes by stimulating bone anabolism and inhibiting bone catabolism.


Levels of hyaluronan in the body are maintained through hyaluronan production (hyaluronan synthases) and hyaluronan turnover(hyaluronidases; mechanical breakdown). Mechanical breakdown of hyaluronan most frequently occurs secondary to tissue damage.


Hyaluronan byproducts (low molecular weight fragments) are removed by the lymph, travel to the liver, and are excreted as waste. Once hyaluronan fragments are recognized, production throughout the body is stimulated. Approximately one-third of the body’s total hyaluronan is turned over daily by this method. This positive feedback loop strives to maintain physiological hyaluronan levels that are tightly controlled.



Hyaluronan is most abundant during fetal development and declines in overall quantity and quality throughout life. For this reason, supplementation with our hyaluronan helps to restore a healthy balance in the body.


Oral hyaluronan is preferred over IV (intra-venous) or IA (intra-articular) administered versions since it eliminates the risk of complications, is more convenient, and more cost effective. Oral hyaluronan is absorbed by mucosal tissues in mouth, esophagus, and gastrointestinal tract. Once absorbed, hyaluronan exploits the body’s natural feedback loop to stimulate systemic production.


Hyaluronex®delivers daily maintenance doses of hyaluronan to naturally enhance joint mobility through shock absorption, lubrication, and articular cartilage nutrition. Our unique formulation is suited for horses of all activity levels and formulated with MHB3®Hyaluronan that is backed by double-blind, placebo-controlled, university studies, holds multiple United States patents, and is used and recommended by leading veterinarians.

suggested use

Use 1/2 oz twice daily for first 7 days followed by 1/2 oz daily maintenance. Increase to 1/2 oz twice daily during periods of increased exercise.



SERVINGS PER CONTAINER: 64OZ – 128 | 128OZ – 256
INGREDIENT:                                    AMOUNT: 

  • MHB3 Hyaluronan                             120MG
  • Hydroxytyrosol                                    90MG
  • Astaxanthin                                         45MG



** Daily Value not established.


Other Ingredients: purified water, sodium chloride, xanthan gum, citric acid, sodium benzoate, potassium sorbate. Contains nothing other than listed ingredients.