Alicaid® partners the gastric perks of MHB3® Hyaluronan and the immune-boosting effects of Betacan Schizophyllan. This formulation works to improve the quality of life of canines suffering from stomach discomfort and promote health and overall well-being. Exogenous hyaluronan (HA) administration has been shown to be safe and effective at combating a multitude of undesirable physiological states.
Hyaluronan is often used as a means of dampening the unpleasant gastrointestinal side effects caused by other therapies. Gastric complications often lead to decreased food intake, lethargy, and failure to thrive. A supplement combining both the gastric protection of MHB3 Hyaluronan and the immune-boosting effects of Betacan Schizophyllan offers clinical benefit and improvement to the quality of life of those dogs susceptible to gastrointestinal side effects.
Schizophyllan is beta glucan derived from the cell wall of the Schizophyllum commune mushroom. Beta-glucans can be derived from multiple sources including grains and mushrooms. They are widely recognized for their immune benefits. Beta-glucans derived from water soluble mushrooms are considered the most effective and are proven in their ability to enhance the immune response.
Schizophyllan is a proven biological defense modifier that nutritionally potentiates the immune response. This immune activation occurs by schizophyllan's ability to directly target immune cells in the host. Molecularly speaking, schizophyllan is classified as a 1,3-1,6 beta glucan. Beta glucans in this configuration have been shown to elicit a more effective physiological response.
As a beta glucan, schizophyllan is generally recognized as safe (GRAS) by the US FDA.
Hyaluronan is the accepted scientific nomenclature for hyaluronic acid (HA) and physiological salts of hyaluronate, the conjugate base of hyaluronic acid. Hyaluronan is classified as a glycosaminoglycan (GAG), a long, unbranched polysaccharide made of repeating disaccharides of glucuronic acid and glucosamine (Fraser, 1997). The polymer chain of hyaluronan ranges in molecular weight from hundreds of units (or Daltons) up to several million.
Hyaluronan is found ubiquitously throughout the mammalian body. It is either directly or indirectly involved in every physiological function of the body. It is found in dense concentrations in cartilage, synovial fluid, skin, vertebral discs, bones, urinary tract, cardiac valves, eyes, and various other soft tissue. Hyaluronan is most abundant during embryogenesis and declines in overall quantity and quality throughout life (McDonald, 2002).
Canonically, hyaluronan is recognized for its role in the maintenance of joint health. It is the presence of hyaluronan that makes cartilage strong enough to handle compressive forces within the joint (Seog, 2002). Hyaluronan is also found in the synovial fluid, where it provides the major source of lubrication that allows for smooth fluid movements in joints (Sabaratnam, 2005). Within bone itself, the presence of hyaluronan is primarily linked to its roles in bone modeling and remodeling processes.
Hyaluronan makes up a large part of the vitreous humor of the eye where it provides ocular moisturization and lubrication.
Hyaluronan has established itself as a protectant by its ability to confer defense to gut mucosal tissue. A recent study aimed to evaluate the effects of hyaluronan on gastric mucosa (Al-Bayaty 2011). Laboratory findings revealed that a high-molecular-weight hyaluronan-containing gel significantly protected the gastric mucosa.
Oral viscosupplementation of hyaluronan is preferential to injectable products because it eliminates the risk of adverse reactions, is more convenient, and more cost effective (Spirito, 2011).
Oral hyaluronan has been shown to be absorbed and effective (Ma, 2008). Recent clinical studies are consistent with these laboratory findings (Lukens, 2005; Kiburz, 2006). Studies with labeled, high-molecular-weight hyaluronan administered orally show distribution to the joints in as little as four hours post-administration (Balough, 2008).
Clearly, there is the potential for benefit from hyaluronan treatment as exogenous hyaluronan administration and supplementation has been shown to be safe and effective.
To be compared to the CSG family of products, any oral hyaluronan supplement must be bioavailable, absorbed, and effective. Hyaluronan must be completely hydrated in order to be bioavailable and absorbed. Once absorbed it must have the appropriate molecular characteristics to be effective.
Alicaid is vegan, gluten-free, and non-GMO.