Alimend eases equine stomach discomfort while promoting healthy stomach pH and digestion. It is safe for continuous daily use and complies with equine anti-doping regulations. Our patent-pending formulation is researched and recommended by leading veterinarians. Alimend is made in Lexington, Kentucky, and contains fully traceable, human-grade ingredients.
Prevalence of digestive complications is high among confined horses and can reach 90%1. Often, this is directly related to many common animal husbandry techniques: confinement, feed, feeding, pre-performance fasting, continuous daily exercise, periods of maximum exertion, NSAID use, and repeated electrolyte use2.
Horses are herbivores whose digestive systems are adapted to a forage diet of grasses and other plant material consumed throughout the day3. As a result, horses are continuous acid secretors, and secrete gastric acids constantly. Compared to humans who are stimulated acid secretors, horses have a relatively small stomach but very long intestines to facilitate a steady flow of nutrients4. While comparatively small, the horse stomach is a diverse microenvironment. The pH at the inlet (cardiac sphincter) is near neutral (6-7) and becomes very acidic (1-2) at the outlet (pyloric sphincter)5. Disturbing this delicate balance in the horses' stomach can have serious ramifications.
Altering the pH of an equine stomach can cause incomplete digestion, poor nutrient absorption, and colic - a leading cause of death in horses6.
Current management options for horses affect stomach pH, are not indicated for long-term use, and are based on human biology. Thus, existing options are designed for stimulated acid secretors and alter and/or halt digestive acid secretion to passively address the problem.
Alimend's polysaccharides work with the horses' biology and not against it. Alimend does not alter stomach pH. Alimend exploits the mucoadhesive properties of hyaluronan and schizophyllan in a novel way to address digestive complications.
Schizophyllan is a 1, 3-1, 6 beta glucan derived from the cell wall of the Schizophyllum commune mushroom7. Beta-glucans can be derived from multiple sources including grains and mushrooms and are widely recognized for their immune benefits. Beta-glucans derived from water soluble mushrooms are considered the most effective in their ability to enhance the immune response8.
Schizophyllan is a biological defense modifier that nutritionally potentiates the immune response. This immune activation occurs via schizophyllan's ability to directly target immune cells in the host. 1, 3-1, 6 beta glucans elicit a more effective physiological response7,8,9.
As a beta glucan, schizophyllan is generally recognized as safe (GRAS) by the US FDA.
Hyaluronan, also known as hyaluronic acid (HA) is a long, unbranched polysaccharide. The polymer chain of hyaluronan ranges in molecular weight from hundreds of units (or Daltons) up to several million10.
Hyaluronan is found throughout the mammalian body and is either directly or indirectly involved in every physiological function of the body. Hyaluronan is found in dense concentrations in cartilage, synovial fluid, skin, vertebral discs, bones, urinary tract, cardiac valves, eyes, and various other soft tissues10. Hyaluronan is most abundant during embryogenesis and declines in overall quantity and quality throughout life.
HA is primarily recognized for its role in the maintenance of joint health. However, it has recently established itself as a protectant of gut mucosal tissue. A recent study revealed that an 0.8% hyaluronan-containing gel significantly protected the gastric mucosa and outperformed the current standard of care11,12.
While the mechanism of gastric support by polysaccharides has yet to be fully elucidated, a hyaluronan-containing polysaccharide blend works in part as a gastric coating/binding agent due to its bioadhesive properties13.
Oral supplementation of hyaluronan has been shown to be absorbed and effective. Studies with labeled, high-molecular-weight hyaluronan administered orally show systemic distribution in as little as four hours post-administration14.
Oral hyaluronan must be fully hydrated to be bioavailable and absorbed. Once absorbed it must have the appropriate molecular characteristics to be effective. Pellets, tablets, capsules, and other dry forms are not bioavailable.
Alimend® supports stomach health in horses. Alimend is specifically formulated to address stomach discomfort associated with training, travel, and performance related stress. Routine use of Alimend results in 24/7 stomach comfort.